Therapeutic challenges in small cell carcinoma of the larynx.
BMJ Case Rep
; 17(1)2024 Jan 23.
Article
in En
| MEDLINE
| ID: mdl-38262714
ABSTRACT
Primary small cell neuroendocrine carcinoma (SCNC) of the larynx is a rare subtype of laryngeal cancer, accounting for less than 1% of all laryngeal tumours. It most commonly affects smokers in their fifth to sixth decade of life and is characterised by a high incidence of advanced disease at presentation and an aggressive clinical course. Here we present a case of SCNC of the larynx, presenting initially with dysphonia, and an associated literature review collating current knowledge regarding therapeutic approaches. After review of 260 cases in the literature we determined a disease-specific survival of 33.1%. Combined chemoradiotherapy is currently the recommended first-line treatment option.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Laryngeal Neoplasms
/
Carcinoma, Small Cell
/
Small Cell Lung Carcinoma
/
Larynx
/
Lung Neoplasms
Limits:
Humans
Language:
En
Journal:
BMJ Case Rep
Year:
2024
Type:
Article
Affiliation country:
Australia