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The inhibition of several components of terminal complement pathway results in C3 binding to PNH red blood cells.
Sica, Michela; Notaro, Rosario.
Affiliation
  • Sica M; Laboratory of Cancer Genetics and Gene Transfer, Core Research Laboratory, Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Florence, Italy.
  • Notaro R; Laboratory of Cancer Genetics and Gene Transfer, Core Research Laboratory, Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Florence, Italy.
Am J Hematol ; 99(3): 505-507, 2024 03.
Article in En | MEDLINE | ID: mdl-38264841
ABSTRACT
C3 binding on PNH red blood cells after in vitro complement activation in normal and terminal complement depleted (∆5, ∆6, ∆9) sera C3 binding, and the subsequent extravascular hemolysis, happens anytime there is a block of a component of the terminal complement pathway.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hemoglobinuria, Paroxysmal Limits: Humans Language: En Journal: Am J Hematol Year: 2024 Type: Article Affiliation country: Italy

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hemoglobinuria, Paroxysmal Limits: Humans Language: En Journal: Am J Hematol Year: 2024 Type: Article Affiliation country: Italy