Rapid Development of Achalasia After SARS-CoV-2 Infection: Polymerase Chain Reaction Analysis of Esophageal Muscle Tissue.
Am J Gastroenterol
; 119(5): 987-990, 2024 05 01.
Article
in En
| MEDLINE
| ID: mdl-38265043
ABSTRACT
INTRODUCTION:
Achalasia has been linked to viruses. We have observed cases of rapid-developing achalasia post-coronavirus disease 2019 (COVID-19).METHODS:
We aimed to prospectively evaluate esophageal muscle for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from patients with rapid-onset achalasia post-COVID-19 and compare them with achalasia predating COVID-19 and achalasia with no COVID-19.RESULTS:
Compared with long-standing achalasia predating COVID-19 and long-standing achalasia with no COVID-19, the subjects with achalasia post-COVID-19 had significantly higher levels of messenger RNA for the SARS-CoV-2 nucleocapsid (N) protein, which correlated with a significant increase in the inflammatory markers NOD-like receptor family pyrin domain-containing 3 and tumor necrosis factor.DISCUSSION:
SARS-CoV-2, the virus responsible for COVID-19, is a possible trigger for achalasia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Esophageal Achalasia
/
SARS-CoV-2
/
COVID-19
Limits:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Am J Gastroenterol
Year:
2024
Type:
Article
Affiliation country:
United States