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Co-representation of Functional Brain Networks Is Shaped by Cortical Myeloarchitecture and Reveals Individual Behavioral Ability.
Chu, Congying; Li, Wen; Shi, Weiyang; Wang, Haiyan; Wang, Jiaojian; Liu, Yong; Liu, Bing; Elmenhorst, David; Eickhoff, Simon B; Fan, Lingzhong; Jiang, Tianzi.
Affiliation
  • Chu C; Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
  • Li W; Institute of Neuroscience and Medicine (INM-2), Forschungszentrum Jülich, Jülich 52428, Germany.
  • Shi W; Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
  • Wang H; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Wang J; Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
  • Liu Y; Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
  • Liu B; State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China.
  • Elmenhorst D; School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing 100876, China.
  • Eickhoff SB; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.
  • Fan L; Institute of Neuroscience and Medicine (INM-2), Forschungszentrum Jülich, Jülich 52428, Germany.
  • Jiang T; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Forschungszentrum Jülich, Jülich 52428, Germany.
J Neurosci ; 44(13)2024 Mar 27.
Article in En | MEDLINE | ID: mdl-38290847
ABSTRACT
Large-scale functional networks are spatially distributed in the human brain. Despite recent progress in differentiating their functional roles, how the brain navigates the spatial coordination among them and the biological relevance of this coordination is still not fully understood. Capitalizing on canonical individualized networks derived from functional MRI data, we proposed a new concept, that is, co-representation of functional brain networks, to delineate the spatial coordination among them. To further quantify the co-representation pattern, we defined two indexes, that is, the co-representation specificity (CoRS) and intensity (CoRI), for separately measuring the extent of specific and average expression of functional networks at each brain location by using the data from both sexes. We found that the identified pattern of co-representation was anchored by cortical regions with three types of cytoarchitectural classes along a sensory-fugal axis, including, at the first end, primary (idiotypic) regions showing high CoRS, at the second end, heteromodal regions showing low CoRS and high CoRI, at the third end, paralimbic regions showing low CoRI. Importantly, we demonstrated the critical role of myeloarchitecture in sculpting the spatial distribution of co-representation by assessing the association with the myelin-related neuroanatomical and transcriptomic profiles. Furthermore, the significance of manifesting the co-representation was revealed in its prediction of individual behavioral ability. Our findings indicated that the spatial coordination among functional networks was built upon an anatomically configured blueprint to facilitate neural information processing, while advancing our understanding of the topographical organization of the brain by emphasizing the assembly of functional networks.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Brain Mapping Type of study: Prognostic_studies Limits: Female / Humans / Male Language: En Journal: J Neurosci Year: 2024 Type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Brain Mapping Type of study: Prognostic_studies Limits: Female / Humans / Male Language: En Journal: J Neurosci Year: 2024 Type: Article Affiliation country: China