Morin ameliorates myocardial injury in diabetic rats via modulation of inflammatory pathways.
Lab Anim Res
; 40(1): 3, 2024 Feb 09.
Article
in En
| MEDLINE
| ID: mdl-38331877
ABSTRACT
BACKGROUND:
High blood glucose levels in diabetes lead to vascular inflammation which accelerates atherosclerosis. Herein, Morin was orally administered in male Wistar rats, at the dose of 40 mg/kg for 28 days, and on the 27th and 28th day, ISO was administered to designate groups at the dose of 85 mg/kg s.c., to induce myocardial infarction.RESULTS:
Free radical generation, including ROS, in diabetes following ISO administration, leads to the activation of both intrinsic and extrinsic pathways of apoptosis. Morin significantly (p ≤ 0.05) reduced oxidative stress (GSH, MDA, SOD), cardiac injury markers (CK-MB, LDH), inflammation (TNF, IL-6), and apoptosis (Bax, BCl2, Caspase-3). In addition, it also reduced insulin and blood glucose levels. Akt/eNOS, Nrf2/HO-1, MAPK signaling pathways, and Insulin signal transduction pathways were positively modulated by morin pre-treatment.CONCLUSIONS:
Morin attenuated oxidative stress and inflammation and also modified the activity of various molecular pathways to mitigate cardiomyocyte damage during ISO-induced MI in diabetic rats.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Lab Anim Res
Year:
2024
Type:
Article
Affiliation country:
India