Your browser doesn't support javascript.
loading
Genome-wide association analysis of composite sleep health scores in 413,904 individuals.
Goodman, Matthew O; Faquih, Tariq; Paz, Valentina; Nagarajan, Pavithra; Lane, Jacqueline M; Spitzer, Brian; Maher, Matthew; Chung, Joon; Cade, Brian E; Purcell, Shaun M; Zhu, Xiaofeng; Noordam, Raymond; Phillips, Andrew J K; Kyle, Simon D; Spiegelhalder, Kai; Weedon, Michael N; Lawlor, Deborah A; Rotter, Jerome I; Taylor, Kent D; Isasi, Carmen R; Sofer, Tamar; Dashti, Hassan S; Rutter, Martin K; Redline, Susan; Saxena, Richa; Wang, Heming.
Affiliation
  • Goodman MO; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
  • Faquih T; Department of Neurology and Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Paz V; Broad Institute, Cambridge, MA, USA.
  • Nagarajan P; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
  • Lane JM; Department of Neurology and Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Spitzer B; Broad Institute, Cambridge, MA, USA.
  • Maher M; Instituto de Psicología Clínica, Facultad de Psicología, Universidad de la República, Montevideo, Uruguay.
  • Chung J; MRC Unit for Lifelong Health & Ageing, Institute of Cardiovascular Science, University College London, London, United Kingdom.
  • Cade BE; Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Purcell SM; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
  • Zhu X; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
  • Noordam R; Department of Neurology and Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Phillips AJK; Broad Institute, Cambridge, MA, USA.
  • Kyle SD; Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Spiegelhalder K; Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Weedon MN; Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Lawlor DA; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
  • Rotter JI; Department of Neurology and Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Taylor KD; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
  • Isasi CR; Department of Neurology and Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Sofer T; Broad Institute, Cambridge, MA, USA.
  • Dashti HS; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
  • Rutter MK; Department of Neurology and Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Redline S; Broad Institute, Cambridge, MA, USA.
  • Saxena R; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
  • Wang H; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
medRxiv ; 2024 Feb 03.
Article in En | MEDLINE | ID: mdl-38352337
ABSTRACT
Recent genome-wide association studies (GWASs) of several individual sleep traits have identified hundreds of genetic loci, suggesting diverse mechanisms. Moreover, sleep traits are moderately correlated, and together may provide a more complete picture of sleep health, while also illuminating distinct domains. Here we construct novel sleep health scores (SHSs) incorporating five core self-report

measures:

sleep duration, insomnia symptoms, chronotype, snoring, and daytime sleepiness, using additive (SHS-ADD) and five principal components-based (SHS-PCs) approaches. GWASs of these six SHSs identify 28 significant novel loci adjusting for multiple testing on six traits (p<8.3e-9), along with 341 previously reported loci (p<5e-08). The heritability of the first three SHS-PCs equals or exceeds that of SHS-ADD (SNP-h2=0.094), while revealing sleep-domain-specific genetic discoveries. Significant loci enrich in multiple brain tissues and in metabolic and neuronal pathways. Post GWAS analyses uncover novel genetic mechanisms underlying sleep health and reveal connections to behavioral, psychological, and cardiometabolic traits.
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: MedRxiv Year: 2024 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: MedRxiv Year: 2024 Type: Article Affiliation country: United States