Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization.
Int Endod J
; 57(5): 566-575, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38411530
ABSTRACT
AIM:
This current Mendelian randomization (MR) study aims to comprehensively explore the potential bidirectional link between pulp and periapical disease (PAP) with type 2 diabetes mellitus (T2DM).METHODOLOGY:
Summary level data of European-based population genome-wide association studies (GWASs) were employed to undertake this MR study. With the selection of single nucleotide polymorphisms (SNPs) as the instrumental variable, the radial inverse-variance weighted (radial IVW) method with modified second-order weights was applied as the primary method. Additionally, a range of sensitivity analyses were conducted to investigate pleiotropy. Results from different sources of outcome were pooled by meta-analysis with the fixed model.RESULTS:
The results of this MR analysis did not suggest a significant impact of pulp and periapical disease on type 2 diabetes (combined OR = 1.04, 95% CI 1.00-1.07, p = .033) and vice versa (OR = 1.04, 95% CI 0.96-1.14, p = .329). No significant pleiotropy was detected in the final model after the removal of outliers, demonstrating the reliability of the results in our primary analysis.CONCLUSIONS:
With the limitations inherent in the present MR study, there is no significant evidence in either direction to suggest a causal association between pulp and periapical disease and type 2 diabetes mellitus.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Periapical Diseases
/
Dental Pulp Diseases
/
Diabetes Mellitus, Type 2
Limits:
Humans
Language:
En
Journal:
Int Endod J
Year:
2024
Type:
Article
Affiliation country:
China