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A guideline on the molecular ecosystem regulating ferroptosis.
Dai, Enyong; Chen, Xin; Linkermann, Andreas; Jiang, Xuejun; Kang, Rui; Kagan, Valerian E; Bayir, Hülya; Yang, Wan Seok; Garcia-Saez, Ana J; Ioannou, Maria S; Janowitz, Tobias; Ran, Qitao; Gu, Wei; Gan, Boyi; Krysko, Dmitri V; Zhu, Xiaofeng; Wang, Jiayi; Krautwald, Stefan; Toyokuni, Shinya; Xie, Yangchun; Greten, Florian R; Yi, Qing; Schick, Joel; Liu, Jiao; Gabrilovich, Dmitry I; Liu, Jinbao; Zeh, Herbert J; Zhang, Donna D; Yang, Minghua; Iovanna, Juan; Kopf, Manfred; Adolph, Timon E; Chi, Jen-Tsan; Li, Changfeng; Ichijo, Hidenori; Karin, Michael; Sankaran, Vijay G; Zou, Weiping; Galluzzi, Lorenzo; Bush, Ashley I; Li, Binghui; Melino, Gerry; Baehrecke, Eric H; Lotze, Michael T; Klionsky, Daniel J; Stockwell, Brent R; Kroemer, Guido; Tang, Daolin.
Affiliation
  • Dai E; Department of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun, China. daiey@jlu.edu.cn.
  • Chen X; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
  • Linkermann A; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
  • Jiang X; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, NY, USA.
  • Kang R; Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Kagan VE; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Bayir H; Department of Environmental Health, University of Pittsburgh, Pittsburgh, PA, USA.
  • Yang WS; Department of Pediatrics, Columbia University, New York, NY, USA.
  • Garcia-Saez AJ; Department of Biological Sciences, St. John's University, New York, NY, USA.
  • Ioannou MS; Institute for Genetics, CECAD, University of Cologne, Cologne, Germany.
  • Janowitz T; Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.
  • Ran Q; Cold Spring Harbor Laboratory, New York, USA.
  • Gu W; Department of Cell Systems and Anatomy, South Texas Veterans Health Care System, San Antonio, TX, USA.
  • Gan B; Institute for Cancer Genetics, and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
  • Krysko DV; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Zhu X; Cell Death Investigation and Therapy (CDIT) Laboratory, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
  • Wang J; Cancer Research Institute Ghent, Ghent, Belgium.
  • Krautwald S; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, and Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Toyokuni S; Department of Clinical Laboratory, Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital and College of Medical Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Xie Y; Department of Nephrology and Hypertension, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Greten FR; Department of Pathology and Biological Response, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Yi Q; Center for Low-Temperature Plasma Sciences, Nagoya University, Nagoya, Japan.
  • Schick J; Department of Oncology, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Liu J; Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt am Main, Germany.
  • Gabrilovich DI; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany.
  • Liu J; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Zeh HJ; Houston Methodist Neal Cancer Center/Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas, USA.
  • Zhang DD; Genetics and Cellular Engineering Group, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich, Neuherberg, Germany.
  • Yang M; DAMP Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Iovanna J; AstraZeneca, Early Oncology R&D, Gaithersburg, MD, USA.
  • Kopf M; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
  • Adolph TE; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Chi JT; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA.
  • Li C; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.
  • Ichijo H; Hunan Clinical Research Center of Pediatric Cancer, Changsha, China.
  • Karin M; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France.
  • Sankaran VG; Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, Zurich, Switzerland.
  • Zou W; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, and Metabolism, Medical University of Innsbruck, Innsbruck, Austria.
  • Galluzzi L; Department of Molecular Genetics and Microbiology Center for Applied Genomic Technologies, Duke University, Durham, NC, USA.
  • Bush AI; Department of Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, China.
  • Li B; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • Melino G; Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA.
  • Baehrecke EH; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Lotze MT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Klionsky DJ; Departments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Stockwell BR; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
  • Kroemer G; Sandra and Edward Meyer Cancer Center, New York, NY, USA.
  • Tang D; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA.
Nat Cell Biol ; 26(9): 1447-1457, 2024 Sep.
Article in En | MEDLINE | ID: mdl-38424270
ABSTRACT
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipid Peroxidation / Ferroptosis Limits: Animals / Humans Language: En Journal: Nat Cell Biol Year: 2024 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipid Peroxidation / Ferroptosis Limits: Animals / Humans Language: En Journal: Nat Cell Biol Year: 2024 Type: Article Affiliation country: China