Underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic.
Cell
; 187(6): 1374-1386.e13, 2024 Mar 14.
Article
in En
| MEDLINE
| ID: mdl-38428425
ABSTRACT
The World Health Organization declared mpox a public health emergency of international concern in July 2022. To investigate global mpox transmission and population-level changes associated with controlling spread, we built phylogeographic and phylodynamic models to analyze MPXV genomes from five global regions together with air traffic and epidemiological data. Our models reveal community transmission prior to detection, changes in case reporting throughout the epidemic, and a large degree of transmission heterogeneity. We find that viral introductions played a limited role in prolonging spread after initial dissemination, suggesting that travel bans would have had only a minor impact. We find that mpox transmission in North America began declining before more than 10% of high-risk individuals in the USA had vaccine-induced immunity. Our findings highlight the importance of broader routine specimen screening surveillance for emerging infectious diseases and of joint integration of genomic and epidemiological information for early outbreak control.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Communicable Diseases, Emerging
/
Mpox (monkeypox)
/
Epidemics
Limits:
Humans
Language:
En
Journal:
Cell
Year:
2024
Type:
Article