Rosacea: Pathogenesis and Therapeutic Correlates.
J Cutan Med Surg
; 28(2): 178-189, 2024.
Article
in En
| MEDLINE
| ID: mdl-38450615
ABSTRACT
Rosacea is a chronic inflammatory condition of which there is no cure. The pathogenesis of rosacea is likely multifactorial, involving genetic and environmental contributions. Current understanding suggests that pro-inflammatory pathways involving cathelicidins and inflammasome complexes are central to rosacea pathogenesis. Common rosacea triggers modulate these pathways in a complex manner, which may contribute to the varying severity and clinical presentations of rosacea. Established and emerging rosacea treatments may owe their efficacy to their ability to target different players in these pro-inflammatory pathways. Improving our molecular understanding of rosacea will guide the development of new therapies and the use of combination therapies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rosacea
Limits:
Humans
Language:
En
Journal:
J Cutan Med Surg
Journal subject:
DERMATOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Canada