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Impact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort study.
Cezard, Genevieve I; Denholm, Rachel E; Knight, Rochelle; Wei, Yinghui; Teece, Lucy; Toms, Renin; Forbes, Harriet J; Walker, Alex J; Fisher, Louis; Massey, Jon; Hopcroft, Lisa E M; Horne, Elsie M F; Taylor, Kurt; Palmer, Tom; Arab, Marwa Al; Cuitun Coronado, Jose Ignacio; Ip, Samantha H Y; Davy, Simon; Dillingham, Iain; Bacon, Sebastian; Mehrkar, Amir; Morton, Caroline E; Greaves, Felix; Hyams, Catherine; Davey Smith, George; Macleod, John; Chaturvedi, Nishi; Goldacre, Ben; Whiteley, William N; Wood, Angela M; Sterne, Jonathan A C; Walker, Venexia.
Affiliation
  • Cezard GI; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Denholm RE; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
  • Knight R; Population Health Sciences, University of Bristol, Bristol, UK.
  • Wei Y; NIHR Bristol Biomedical Research Centre, Bristol, UK.
  • Teece L; Health Data Research UK South-West, Bristol, UK.
  • Toms R; Population Health Sciences, University of Bristol, Bristol, UK.
  • Forbes HJ; NIHR Bristol Biomedical Research Centre, Bristol, UK.
  • Walker AJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Fisher L; The National Institute for Health and Care Research Applied Research Collaboration West (NIHR ARC West) at University Hospitals Bristol and Weston, Bristol, UK.
  • Massey J; Centre for Mathematical Sciences, School of Engineering, Computing and Mathematics, University of Plymouth, Plymouth, UK.
  • Hopcroft LEM; Department of Population Health Sciences, University of Leicester, Leicester, UK.
  • Horne EMF; Population Health Sciences, University of Bristol, Bristol, UK.
  • Taylor K; Population Wellbeing, School of Health Sciences, Cardiff Metropolitan University, Cardiff, UK.
  • Palmer T; Faculty of Epidemiology and Population Health, London School of Hygiene & tropical Medicine, London, UK.
  • Arab MA; The Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Cuitun Coronado JI; The Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Ip SHY; The Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Davy S; NHS National Services Scotland, Edinburgh, Scotland.
  • Dillingham I; Population Health Sciences, University of Bristol, Bristol, UK.
  • Bacon S; NIHR Bristol Biomedical Research Centre, Bristol, UK.
  • Mehrkar A; Population Health Sciences, University of Bristol, Bristol, UK.
  • Morton CE; Population Health Sciences, University of Bristol, Bristol, UK.
  • Greaves F; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Hyams C; Population Health Sciences, University of Bristol, Bristol, UK.
  • Davey Smith G; Population Health Sciences, University of Bristol, Bristol, UK.
  • Macleod J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Chaturvedi N; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
  • Goldacre B; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Whiteley WN; The Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Wood AM; The Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Sterne JAC; The Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
  • Walker V; The Bennett Institute for Applied Data Science, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Nat Commun ; 15(1): 2173, 2024 Mar 11.
Article in En | MEDLINE | ID: mdl-38467603
ABSTRACT
Infection with SARS-CoV-2 is associated with an increased risk of arterial and venous thrombotic events, but the implications of vaccination for this increased risk are uncertain. With the approval of NHS England, we quantified associations between COVID-19 diagnosis and cardiovascular diseases in different vaccination and variant eras using linked electronic health records for ~40% of the English population. We defined a 'pre-vaccination' cohort (18,210,937 people) in the wild-type/Alpha variant eras (January 2020-June 2021), and 'vaccinated' and 'unvaccinated' cohorts (13,572,399 and 3,161,485 people respectively) in the Delta variant era (June-December 2021). We showed that the incidence of each arterial thrombotic, venous thrombotic and other cardiovascular outcomes was substantially elevated during weeks 1-4 after COVID-19, compared with before or without COVID-19, but less markedly elevated in time periods beyond week 4. Hazard ratios were higher after hospitalised than non-hospitalised COVID-19 and higher in the pre-vaccination and unvaccinated cohorts than the vaccinated cohort. COVID-19 vaccination reduces the risk of cardiovascular events after COVID-19 infection. People who had COVID-19 before or without being vaccinated are at higher risk of cardiovascular events for at least two years.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / COVID-19 Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / COVID-19 Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Type: Article Affiliation country: United kingdom