Novel high-resolution contrast agent ultrasound techniques HiFR CEUS and SR CEUS in combination with shear wave elastography, fat assessment and viscosity of liver parenchymal changes and tumors.
Clin Hemorheol Microcirc
; 86(3): 263-273, 2024.
Article
in En
| MEDLINE
| ID: mdl-38489171
ABSTRACT
BACKGROUND:
The continuous development of ultrasound techniques increasingly enables better description and visualization of unclear lesions. New ultrasound systems must be evaluated with regard to all these diagnostic possibilities.METHODS:
A multifrequency C1-7 convex probe (SC7-1M) with the new high-end system Resona A20 Series was used. Modern technologies, including HiFR CEUS, SR CEUS and multimodal tissue imaging with shear wave elastography (SWE), fat evaluation and viscosity measurements (M-Ref) were applied.RESULTS:
Of nâ=â70 (mean value 48,3 years±20,3 years, range 18-84 years) cases examined, a definitive diagnosis could be made in nâ=â67 cases, confirmed by reference imaging and/or follow-up. Of these, nâ=â22 cases were malignant changes (HCC (hepatocellular carcinoma) nâ=â9, CCC (cholangiocellular carcinoma) nâ=â3, metastases of colorectal carcinomas or recurrences of HCC nâ=â10). In all 12 cases of HCC or CCC, the elastography measurements using the shear wave technique (with values >2âm/s to 3.7âm/s) showed mean values of 2.3±0.31âm/s and a degree of fibrosis of F2 to F4. In nâ=â14 cases, changes in the fat measurement (range 0.51 to 0.72âdB/cm/MHz, mean values 0.58±0.12âdB/cm/MHz) in the sense of proportional fatty changes in the liver were detected. In the 4 cases of localized fat distribution disorders, the values were >0.7âdB/cm/MHz in the sense of significant fatty deposits in the remaining liver tissue. Relevant changes in the viscosity measurements with values >1.8âkPa were found in nâ=â31 cases, in nâ=â5 cases of cystic lesions with partially sclerosing cholangitis, in nâ=â13 cases of malignant lesions and in nâ=â9 cases post-interventionally, but also in nâ=â4 cases of benign foci with additional systemic inflammation.CONCLUSIONS:
The results are promising and show a new quality of ultrasound-based liver diagnostics. However, there is a need for further investigations with regard to the individual aspects, preferably on a multi-center basis.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Hepatocellular
/
Elasticity Imaging Techniques
/
Liver Neoplasms
Limits:
Humans
Language:
En
Journal:
Clin Hemorheol Microcirc
Journal subject:
ANGIOLOGIA
/
HEMATOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Germany