Dementias Platform UK: Bringing genetics into life.
Alzheimers Dement
; 20(5): 3281-3289, 2024 05.
Article
in En
| MEDLINE
| ID: mdl-38506636
ABSTRACT
INTRODUCTION:
The Dementias Platform UK (DPUK) Data Portal is a data repository bringing together a wide range of cohorts. Neurodegenerative dementias are a group of diseases with highly heterogeneous pathology and an overlapping genetic component that is poorly understood. The DPUK collection of independent cohorts can facilitate research in neurodegeneration by combining their genetic and phenotypic data.METHODS:
For genetic data processing, pipelines were generated to perform quality control analysis, genetic imputation, and polygenic risk score (PRS) derivation with six genome-wide association studies of neurodegenerative diseases. Pipelines were applied to five cohorts.DISCUSSION:
The data processing pipelines, research-ready imputed genetic data, and PRS scores are now available on the DPUK platform and can be accessed upon request though the DPUK application process. Harmonizing genome-wide data for multiple datasets increases scientific opportunity and allows the wider research community to access and process data at scale and pace.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Multifactorial Inheritance
/
Dementia
/
Genome-Wide Association Study
Limits:
Humans
Country/Region as subject:
Europa
Language:
En
Journal:
Alzheimers Dement
Year:
2024
Type:
Article