Association between the ROX index and mortality in patients with acute hypoxemic respiratory failure: a retrospective cohort study.
Respir Res
; 25(1): 143, 2024 Mar 29.
Article
in En
| MEDLINE
| ID: mdl-38553757
ABSTRACT
BACKGROUND:
Although ROX index is frequently used to assess the efficacy of high-flow nasal cannula treatment in acute hypoxemic respiratory failure (AHRF) patients, the relationship between the ROX index and the mortality remains unclear. Therefore, a retrospective cohort study was conducted to evaluate the ability of the ROX index to predict mortality risk in patients with AHRF.METHOD:
Patients diagnosed with AHRF were extracted from the MIMIC-IV database and divided into four groups based on the ROX index quartiles. The primary outcome was 28-day mortality, while in-hospital mortality and follow-up mortality were secondary outcomes. To investigate the association between ROX index and mortality in AHRF patients, restricted cubic spline curve and COX proportional risk regression were utilized.RESULT:
A non-linear association (L-shaped) has been observed between the ROX index and mortality rate. When the ROX index is below 8.28, there is a notable decline in the 28-day mortality risk of patients as the ROX index increases (HR per SD, 0.858 [95%CI 0.794-0.928] P < 0.001). When the ROX index is above 8.28, no significant association was found between the ROX index and 28-day mortality. In contrast to the Q1 group, the mortality rates in the Q2, Q3, and Q4 groups had a substantial reduction (Q1 vs. Q2 HR, 0.749 [0.590-0.950] P = 0.017; Q3 HR, 0.711 [0.558-0.906] P = 0.006; Q4 HR, 0.641 [0.495-0.830] P < 0.001).CONCLUSION:
The ROX index serves as a valuable predictor of mortality risk in adult patients with AHRF, and that a lower ROX index is substantially associated with an increase in mortality.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory Insufficiency
/
Cannula
Limits:
Adult
/
Humans
Language:
En
Journal:
Respir Res
Year:
2024
Type:
Article
Affiliation country:
China