Inappropriate study inclusion in meta-analysis of sham-controlled rTMS for treatment-resistant depression.

ABSTRACT

Dr. Vida and colleagues have published an important meta-analysis on a critical topic in psychiatry the efficacy of double-blind, sham-controlled rTMS in treatment-resistant depression (TRD) [1]. The primary reported finding was a significant effect of rTMS on remission and response (RR 2.25 and 2.78 respectively) compared to sham rTMS. A close evaluation of the studies included in this meta-analysis raises concerns about the accuracy of these findings.