A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells.
Cancer Discov
; 14(6): 920-933, 2024 Jun 03.
Article
in En
| MEDLINE
| ID: mdl-38581442
ABSTRACT
Circulating tumor cells (CTCs) play a pivotal role in metastasis, the leading cause of cancer-associated death. Recent improvements of CTC isolation tools, coupled with a steady development of multiomics technologies at single-cell resolution, have enabled an extensive exploration of CTC biology, unlocking insights into their molecular profiles. A detailed molecular portrait requires CTC interrogation across various levels encompassing genomic, epigenetic, transcriptomic, proteomic and metabolic features. Here, we review how state-of-the-art multiomics applied to CTCs are shedding light on how cancer spreads. Further, we highlight the potential implications of CTC profiling for clinical applications aimed at enhancing cancer diagnosis and treatment. SIGNIFICANCE:
Exploring the complexity of cancer progression through cutting-edge multiomics studies holds the promise of uncovering novel aspects of cancer biology and identifying therapeutic vulnerabilities to suppress metastasis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neoplastic Cells, Circulating
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Cancer Discov
Year:
2024
Type:
Article
Affiliation country:
Switzerland