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Visible-Light-Mediated Three-Component Strategy for the Synthesis of Isoxazolines and Isoxazoles.
Li, Yanchuan; Zhang, Yu; Wang, Jinxin; Xia, Dingding; Zhuo, Miaomiao; Zhu, Lu; Li, Dong; Ni, Shao-Fei; Zhu, Yanping; Zhang, Wei-Dong.
Affiliation
  • Li Y; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
  • Zhang Y; Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai 201203, China.
  • Wang J; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Shandong, Yantai 264005, China.
  • Xia D; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Zhuo M; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Zhu L; Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai 201203, China.
  • Li D; Department of Ophthalmology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
  • Ni SF; Department of Chemistry, Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou 515063, China.
  • Zhu Y; Department of Chemistry, Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou 515063, China.
  • Zhang WD; School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Shandong, Yantai 264005, China.
Org Lett ; 26(15): 3130-3134, 2024 Apr 19.
Article in En | MEDLINE | ID: mdl-38587308
ABSTRACT
Isoxazolines and isoxazoles commonly serve as core structures of many therapeutic agents and natural products. However, the metal-free and catalysis-free strategy for the synthesis of these privileged motifs at room temperature remains a challenging task. Herein, we report a three-component strategy to afford diverse isoxazolines and isoxazoles via [3 + 2] cycloadditions of in situ-formed nitronates and olefins/alkynes under visible-light irradiation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2024 Type: Article Affiliation country: China
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2024 Type: Article Affiliation country: China