The role of the c-mos gene in the 8;21 translocation in human acute myeloblastic leukemia.
Science
; 229(4715): 767-9, 1985 Aug 23.
Article
in En
| MEDLINE
| ID: mdl-3860954
ABSTRACT
The human c-mos proto-oncogene is located on chromosome 8 at band q22, close to the breakpoint in the t(8;21) (q22;q22) chromosome rearrangement. This translocation is associated with acute myeloblastic leukemia, subgroup M2. The c-myc gene, another proto-oncogene, has been mapped to 8q24. The breakpoint at 8q22 separates these genes, as determined by in situ hybridization of c-mos and c-myc probes. The c-mos gene remains on the 8q-chromosome and the c-myc gene is translocated to the 21q+ chromosome. Southern blot analysis of DNA from bone marrow cells of four patients with this translocation showed no rearrangement of c-mos.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oncogenes
/
Translocation, Genetic
/
Leukemia, Myeloid, Acute
/
Chromosomes, Human, 21-22 and Y
/
Chromosomes, Human, 6-12 and X
Limits:
Humans
Language:
En
Journal:
Science
Year:
1985
Type:
Article