The emerging role of deubiquitylating enzyme USP21 as a potential therapeutic target in cancer.
Bioorg Chem
; 147: 107400, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38688196
ABSTRACT
Although certain members of the Ubiquitin-specific peptidases (USPs) have been recognized as promising therapeutic targets for various diseases, research progress regarding USP21 has been relatively sluggish in its early stages. USP21 is a crucial member of the USPs subfamily, involved in diverse cellular processes such as apoptosis, DNA repair, and signal transduction. Research findings from the past decade demonstrate that USP21 mediates the deubiquitination of multiple well-known target proteins associated with critical cellular processes relevant to both disease and homeostasis, particularly in various cancers.This reviewcomprehensively summarizes the structure and biological functions of USP21 with an emphasis on its role in tumorigenesis, and elucidates the advances on the discovery of tens of small-molecule inhibitors targeting USP21, which suggests that targeting USP21 may represent a potential strategy for cancer therapy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ubiquitin Thiolesterase
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Bioorg Chem
Year:
2024
Type:
Article
Affiliation country:
China