Antinociceptive effects of gamma-linolenic acid in the formalin test in the rats.
Ann Med Surg (Lond)
; 86(5): 2677-2683, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38694379
ABSTRACT
Background:
Gamma-linolenic acid (GLA) is found in animals and plants that play a role in brain function and metabolism.Objective:
This study aimed to investigate the analgesic effects of GLA on peripheral formalin injection.Methods:
Wistar rats were randomly assigned to four groups Sham, formalin, formalin/GLA 100 mg/kg, and formalin/GLA 150 mg/kg. The Formalin test was utilized to create a pain model. A tissue sample was prepared from the spinal cords of rats to measure oxidative stress parameters and pro-inflammatory cytokines. Furthermore, the authors analyzed the expression of c-Fos protein in the spinal cords.Results:
Our findings demonstrate that GLA has a reliable pain-relieving effect in the formalin test. GLA 100 increased superoxide dismutase (SOD) (P<0.05), glutathione (GSH) (P<0.001), and catalase (CAT) (P<0.05), and decreased the levels of c-Fos (P<0.001), interleukin-1 beta (IL-1ß) (P<0.001), tumour necrosis factor-alpha (TNF-α) (P<0.001), and malondialdehyde (MDA) (P<0.001) in the spinal cord. Also GLA 150 increased SOD (P<0.05), GSH (P<0.001), and CAT (P<0.05) and decreased the levels of c-Fos (P<0.001), IL-1ß (P<0.001), TNF-α (P<0.001), and MDA (P<0.001) in the spinal cord.Conclusion:
The findings have validated the antinociceptive impact of GLA and hinted towards its immunomodulatory influence in the formalin test.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Ann Med Surg (Lond)
Year:
2024
Type:
Article