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Clinicopathologic conference: Bloodstream infection in an allogeneic hamatopoietic cell transplant: Thinking beyond the usual.
Yeoh, Kim; Lass-Flörl, Cornelia; Lamoth, Frédéric; Slavin, Monica A; Williams, Eloise; Neofytos, Dionysios.
Affiliation
  • Yeoh K; Department of Microbiology, The Royal Melbourne Hospital, Melbourne, Australia.
  • Lass-Flörl C; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Lamoth F; Department of Hygiene, Microbiology and Social Medicine, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
  • Slavin MA; Department of Medicine, Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Williams E; Department of Laboratory Medicine and Pathology, Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Neofytos D; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Transpl Infect Dis ; 26(4): e14273, 2024 Aug.
Article in En | MEDLINE | ID: mdl-38695847
ABSTRACT
This case involves a 53-year-old female with concurrent acute myeloid leukemia (AML) and multiple myeloma. She underwent cytarabine and daunorubicin (7+3) induction chemotherapy followed by cytarabine (HiDAC) consolidation, with an early AML relapse requiring azacitidine and venetoclax therapy. She achieved complete remission and incomplete count recovery. Following fludarabine, melphalan, and thymoglobulin induction chemotherapy, she underwent an allogeneic stem cell transplant with failure to engraft, requiring autologous stem cell rescue, buffy coat, and granulocyte transfusions, eventually presenting with a diffuse skin rash consistent with Steven-Johnson syndrome and toxic epidermal necrolysis, persistent neutropenic fevers and positive blood cultures.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Hematopoietic Stem Cell Transplantation / Multiple Myeloma Limits: Female / Humans / Middle aged Language: En Journal: Transpl Infect Dis Journal subject: TRANSPLANTE Year: 2024 Type: Article Affiliation country: Australia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Hematopoietic Stem Cell Transplantation / Multiple Myeloma Limits: Female / Humans / Middle aged Language: En Journal: Transpl Infect Dis Journal subject: TRANSPLANTE Year: 2024 Type: Article Affiliation country: Australia