Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core.
Nat Prod Bioprospect
; 14(1): 29, 2024 May 14.
Article
in En
| MEDLINE
| ID: mdl-38740677
ABSTRACT
A catalytic diastereoselective Prins reaction for hydroxymethylation and hydroxylation of 1,3-diarylpropene was successfully utilized to prepare various 1,3-dioxanes 7 in 14-88% yields. Take advantage of the synthetic intermediate 7h, the key B/C rings in brazilin core could be constructed by the sequential of Friedel-Crafts/Ullmann-Ma rather than Ullmann-Ma/Friedel-Crafts reactions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Nat Prod Bioprospect
Year:
2024
Type:
Article
Affiliation country:
China