Suberitolactams A-D and Suberitopyridines A-B: New γ-lactam and Pyridine Alkaloids Isolated from the South China Sea Sponge Pseudospongosorites suberitoides.
Chem Biodivers
; 21(8): e202400939, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38752887
ABSTRACT
Four new γ-lactam alkaloids, suberitolactams A-D (1-4), two new pyridine alkaloids, suberitopyridines A-B (7-8), and two known compounds (5-6) were isolated from the South China Sea sponge Pseudospongosorites suberitoides. The structures were elucidated by detailed 1D and 2D NMR experiments along with HRESIMS analysis and single crystal X-ray diffraction. Compoundsâ
1 and 8 showed moderate to weak antiviral activity against H1â
N1 virus with IC50 values of 27.6 and 13.3â
µM, respectively.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Porifera
/
Pyridines
/
Alkaloids
/
Lactams
Limits:
Animals
Country/Region as subject:
Asia
Language:
En
Journal:
Chem Biodivers
/
Chem. biodivers. (Online)
/
Chemistry & biodiversity (Online)
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2024
Type:
Article