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Evaluation of the Therapeutical Effect of Matricaria Chamomilla Extract vs. Galantamine on Animal Model Memory and Behavior Using 18F-FDG PET/MRI.
Iacob, Roxana; Palimariciuc, Matei; Florea, Tudor; Pricope, Cosmin Vasilica; Uritu, Cristina Mariana; Tamba, Bogdan Ionel; Ionescu, Teodor Marian; Stolniceanu, Cati Raluca; Jalloul, Wael; Dobrin, Romeo Petru; Hritcu, Lucian; Cioanca, Oana; Hancianu, Monica; Naum, Alexandru Gratian; Stefanescu, Cipriana.
Affiliation
  • Iacob R; Division of Nuclear Medicine, Department of Biophysics and Medical Physics, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Palimariciuc M; Department of Psychiatry, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Florea T; Department of Psychiatry, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Pricope CV; Advanced Center for Research and Development in Experimental Medicine (CEMEX), "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Uritu CM; Advanced Center for Research and Development in Experimental Medicine (CEMEX), "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Tamba BI; Advanced Center for Research and Development in Experimental Medicine (CEMEX), "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Ionescu TM; Division of Nuclear Medicine, Department of Biophysics and Medical Physics, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Stolniceanu CR; Division of Nuclear Medicine, Department of Biophysics and Medical Physics, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Jalloul W; Division of Nuclear Medicine, Department of Biophysics and Medical Physics, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Dobrin RP; Department of Psychiatry, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Hritcu L; Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania.
  • Cioanca O; Department of Pharmacognosy, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Hancianu M; Department of Pharmacognosy, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Naum AG; Division of Nuclear Medicine, Department of Biophysics and Medical Physics, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
  • Stefanescu C; Division of Nuclear Medicine, Department of Biophysics and Medical Physics, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania.
Curr Issues Mol Biol ; 46(5): 4506-4518, 2024 May 09.
Article in En | MEDLINE | ID: mdl-38785541
ABSTRACT
The memory-enhancing activity of Matricaria chamomilla hydroalcoholic extract (MCE) is already being investigated by behavioral and biochemical assays in scopolamine-induced amnesia rat models, while the effects of scopolamine (Sco) on cerebral glucose metabolism are examined as well. Nevertheless, the study of the metabolic profile determined by an enriched MCE has not been performed before. The present experiments compared metabolic quantification in characteristic cerebral regions and behavioral characteristics for normal, only diseased, diseased, and MCE- vs. Galantamine (Gal)-treated Wistar rats. A memory deficit was induced by four weeks of daily intraperitoneal Sco injection. Starting on the eighth day, the treatment was intraperitoneally administered 30 min after Sco injection for a period of three weeks. The memory assessment comprised three maze tests. Glucose metabolism was quantified after the 18F-FDG PET examination. The right amygdala, piriform, and entorhinal cortex showed the highest differential radiopharmaceutical uptake of the 50 regions analyzed. Rats treated with MCE show metabolic similarity with normal rats, while the Gal-treated group shows features closer to the diseased group. Behavioral assessments evidenced a less anxious status and a better locomotor activity manifested by the MCE-treated group compared to the Gal-treated group. These findings prove evident metabolic ameliorative qualities of MCE over Gal classic treatment, suggesting that the extract could be a potent neuropharmacological agent against amnesia.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Curr Issues Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2024 Type: Article Affiliation country: Romania

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Curr Issues Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2024 Type: Article Affiliation country: Romania