Afatinib-induced toxic epidermal necrolysis: A case report with a literature review.
Br J Clin Pharmacol
; 90(8): 2030-2033, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38803188
ABSTRACT
We present a 70-year-old female patient diagnosed with epidermal growth factor receptor-mutated metastatic non-small cell lung cancer (T4N2M1a), who developed afatinib-induced toxic epidermal necrolysis (TEN). We have also performed a PubMed/Medline literature review to detect other possible cases of TEN/Stevens-Johnson syndrome associated with afatinib treatment and found only 5 other cases reported. To our best knowledge, this is the first case of afatinib-induced TEN successfully treated with cyclosporine.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stevens-Johnson Syndrome
/
Carcinoma, Non-Small-Cell Lung
/
Afatinib
/
Lung Neoplasms
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
Br J Clin Pharmacol
Year:
2024
Type:
Article
Affiliation country:
Croatia