Tubulin Complexity in Cancer and Metastasis.
Adv Exp Med Biol
; 1452: 21-35, 2024.
Article
in En
| MEDLINE
| ID: mdl-38805123
ABSTRACT
Tubulin plays a fundamental role in cellular function and as the subject for microtubule-active agents in the treatment of ovarian cancer. Microtubule-binding proteins (e.g., tau, MAP1/2/4, EB1, CLIP, TOG, survivin, stathmin) and posttranslational modifications (e.g., tyrosination, deglutamylation, acetylation, glycation, phosphorylation, polyamination) further diversify tubulin functionality and may permit additional opportunities to understand microtubule behavior in disease and to develop microtubule-modifying approaches to combat ovarian cancer. Tubulin-based structures that project from suspended ovarian cancer cells known as microtentacles may contribute to metastatic potential of ovarian cancer cells and could represent an exciting novel therapeutic target.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Tubulin
/
Protein Processing, Post-Translational
/
Microtubules
/
Neoplasm Metastasis
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Adv Exp Med Biol
Year:
2024
Type:
Article
Affiliation country:
United States