Spatially resolved tissue imaging to analyze the tumor immune microenvironment: beyond cell-type densities.
J Immunother Cancer
; 12(5)2024 May 31.
Article
in En
| MEDLINE
| ID: mdl-38821717
ABSTRACT
INTRODUCTION:
The tissue immune microenvironment is associated with key aspects of tumor biology. The interaction between the immune system and cancer cells has predictive and prognostic potential across different tumor types. Spatially resolved tissue-based technologies allowed researchers to simultaneously quantify different immune populations in tumor samples. However, bare quantification fails to harness the spatial nature of tissue-based technologies. Tumor-immune interactions are associated with specific spatial patterns that can be measured. In recent years, several computational tools have been developed to increase our understanding of these spatial patterns. TOPICS COVERED In this review, we cover standard techniques as well as new advances in the field of spatial analysis of the immune microenvironment. We focused on marker quantification, spatial intratumor heterogeneity analysis, cellâcell spatial interaction studies and neighborhood analyses.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tumor Microenvironment
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
J Immunother Cancer
Year:
2024
Type:
Article
Affiliation country:
Spain