Subanesthetic Ketamine Suppresses Locus Coeruleus-Mediated Alertness Effects: A 7T fMRI Study.
Int J Neuropsychopharmacol
; 27(6)2024 Jun 01.
Article
in En
| MEDLINE
| ID: mdl-38833581
ABSTRACT
BACKGROUND:
The NMDA antagonist S-ketamine is gaining increasing use as a rapid-acting antidepressant, although its exact mechanisms of action are still unknown. In this study, we investigated ketamine in respect to its properties toward central noradrenergic mechanisms and how they influence alertness behavior.METHODS:
We investigated the influence of S-ketamine on the locus coeruleus (LC) brain network in a placebo-controlled, cross-over, 7T functional, pharmacological MRI study in 35 healthy male participants (25.1 ± 4.2 years) in conjunction with the attention network task to measure LC-related alertness behavioral changes.RESULTS:
We could show that acute disruption of the LC alertness network to the thalamus by ketamine is related to a behavioral alertness reduction.CONCLUSION:
The results shed new light on the neural correlates of ketamine beyond the glutamatergic system and underpin a new concept of how it may unfold its antidepressant effects.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Attention
/
Locus Coeruleus
/
Magnetic Resonance Imaging
/
Cross-Over Studies
/
Ketamine
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Int J Neuropsychopharmacol
Journal subject:
NEUROLOGIA
/
PSICOFARMACOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Germany