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ROS suppression and oocyte quality restoration: NMN intervention in decabromodiphenyl ether-exposed mice.
Jiang, Yi; Cheng, Rong; Zhou, Haoyang; Pu, Yanan; Wang, Di; Jiao, Yangyang; Chen, Yan.
Affiliation
  • Jiang Y; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215000, China.
  • Cheng R; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215000, China.
  • Zhou H; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215000, China.
  • Pu Y; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215000, China.
  • Wang D; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215000, China.
  • Jiao Y; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215000, China.
  • Chen Y; The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215000, China. Electronic address: chenyandoc@njmu.edu.cn.
Ecotoxicol Environ Saf ; 280: 116557, 2024 Jul 15.
Article in En | MEDLINE | ID: mdl-38850695
ABSTRACT
Decabromodiphenyl ether (BDE-209) is an organic compound that is widely used in rubber, textile, electronics, plastics and other industries. It has been found that BDE-209 has a destructive effect on the reproductive system of mammals. However, the effect of BDE-209 exposure on oocyte quality and whether there is a viable salvage strategy have not been reported. Here, we report that murine oocytes exposed to BDE-209 produce a series of meiostic defects, including increased fragmentation rates and decreased PBE. Furthermore, exposure of oocytes to BDE-209 hinders mitochondrial function and disrupts mitochondrial integrity. Our observations show that supplementation with NMN successfully alleviated the meiosis impairment caused by BDE-209 and averted oocyte apoptosis by suppressing ROS generation. In conclusion, our findings suggest that NMN supplementation may be able to alleviate the oocyte quality impairment induced by BDE-209 exposure, providing a potential strategy for protecting oocytes from environmental pollutant exposure.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oocytes / Reactive Oxygen Species / Halogenated Diphenyl Ethers Limits: Animals Language: En Journal: Ecotoxicol Environ Saf Year: 2024 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oocytes / Reactive Oxygen Species / Halogenated Diphenyl Ethers Limits: Animals Language: En Journal: Ecotoxicol Environ Saf Year: 2024 Type: Article Affiliation country: China