Association between adipophilin expression and risk of dyslipidaemia in patients with granuloma annulare.
Med Clin (Barc)
; 163(5): 232-237, 2024 09 13.
Article
in En, Es
| MEDLINE
| ID: mdl-38853069
ABSTRACT
BACKGROUND:
An association between granuloma annulare (GA) and dyslipidaemia has been reported. Adipophilin expression may play a plausible role as a cutaneous biomarker for dyslipidaemia in patients with GA; however, this potential link remains to be explored.METHODS:
Patients with GA were identified at our hospital between January 1, 1990, and December 31, 2021, with a thorough review of their clinical and histological characteristics. Adipophilin staining was assessed in biopsies of GA lesions.RESULTS:
A total of 107 patients with GA were included. The prevalence of dyslipidaemia in patients with positive adipophilin staining was clearly higher than in those with negative labelling (62.3% vs 13.3%). Relative to the dyslipidaemia risk for patients with negative adipophilin expression, the odds for patients with positive adipophilin expression were increased 10-fold (OR 10.8; p-value<.01). We identified 23 incident cases of dyslipidaemia over a median follow-up period of 91 months among 54 patients with no history of dyslipidaemia. The patients with positive adipophilin expression showed a higher risk of developing dyslipidaemia (HR 8.9; p-value<.01).CONCLUSIONS:
Patients with positive adipophilin staining in their GA biopsies were found to be associated with a higher risk for both baseline and incident dyslipidaemia.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Granuloma Annulare
/
Dyslipidemias
/
Perilipin-2
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
/
Es
Journal:
Med Clin (Barc)
/
Med. clin (Ed. impr.)
/
Medicina clinica (Ed. impresa)
Year:
2024
Type:
Article
Affiliation country:
Spain