Metal-catalyzed Markovnikov-type selective hydrofunctionalization of terminal alkynes.
Chem Soc Rev
; 53(14): 7566-7589, 2024 Jul 15.
Article
in En
| MEDLINE
| ID: mdl-38904176
ABSTRACT
Metal-catalyzed highly Markovnikov-type selective hydrofunctionalization of terminal alkynes provides a straightforward and atom-economical route to access 1,1-disubstituted alkenes, which have a wide range of applications in organic synthesis. However, the highly Markovnikov-type selective transformations are challenging due to the electronic and steric effects during the addition process. With the development of metal-catalyzed organic synthesis, different metal catalysts have been developed to solve this challenge, especially for platinum group metal catalysts. In this perspective, we review homogeneous metal-catalyzed Markovnikov-type selective hydrofunctionalization of terminal alkynes according to the classified element types as well as reaction mechanisms. Future avenues for investigation are also presented to help expand this exciting field.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chem Soc Rev
Year:
2024
Type:
Article
Affiliation country:
China