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Identification of a novel target of sulforaphane: Sulforaphane binds to acyl-protein thioesterase 2 (APT2) and attenuates its palmitoylation.
Kodaka, Manami; Kikuchi, Akito; Kawahira, Kotaro; Kamada, Haruhiko; Katsuta, Ryo; Ishigami, Ken; Suzuki, Tsukasa; Yamamoto, Yuji; Inoue, Jun.
Affiliation
  • Kodaka M; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, Japan. Electronic address: manatee.ko@gmail.com.
  • Kikuchi A; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, Japan. Electronic address: akito0111oyakata@gmail.com.
  • Kawahira K; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, Japan. Electronic address: 10323009@nodai.ac.jp.
  • Kamada H; Laboratory of Biopharmaceutical Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan. Electronic address: kamada@nibiohn.go.jp.
  • Katsuta R; Department of Chemistry for Life Sciences and Agriculture, Tokyo University of Agriculture, Tokyo, Japan. Electronic address: r3katsut@nodai.ac.jp.
  • Ishigami K; Department of Chemistry for Life Sciences and Agriculture, Tokyo University of Agriculture, Tokyo, Japan. Electronic address: ki206171@nodai.ac.jp.
  • Suzuki T; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, Japan. Electronic address: ts200635@nodai.ac.jp.
  • Yamamoto Y; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, Japan. Electronic address: yujiya@nodai.ac.jp.
  • Inoue J; Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, Japan. Electronic address: ji206785@nodai.ac.jp.
Biochem Biophys Res Commun ; 726: 150244, 2024 Sep 24.
Article in En | MEDLINE | ID: mdl-38905785
ABSTRACT
Sulforaphane (SFaN) is a food-derived compound with several bioactive properties, including atherosclerosis, diabetes, and obesity treatment. However, the mechanisms by which SFaN exerts its various effects are still unclear. To elucidate the mechanisms of the various effects of SFaN, we explored novel SFaN-binding proteins using SFaN beads and identified acyl protein thioesterase 2 (APT2). We also found that SFaN binds to the APT2 via C56 residue and attenuates the palmitoylation of APT2, thereby reducing plasma membrane localization of APT2. This study reveals a novel bioactivity of SFaN as a regulator of APT2 protein palmitoylation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfoxides / Thiolester Hydrolases / Isothiocyanates / Lipoylation Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2024 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfoxides / Thiolester Hydrolases / Isothiocyanates / Lipoylation Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2024 Type: Article