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Case report: Pediatric low-grade gliomas: a fine balance between treatment options, timing of therapy, symptom management and quality of life.
Joh-Carnella, Nicolette; Bauman, Glenn; Yock, Torunn I; Zelcer, Shayna; Youkhanna, Sabin; Cacciotti, Chantel.
Affiliation
  • Joh-Carnella N; Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • Bauman G; Division of Radiation Oncology, Department of Oncology, London Health Sciences Centre & Western University, London, ON, Canada.
  • Yock TI; Department of Pediatric Radiation Oncology, Massachusetts General Hospital, Boston, MA, United States.
  • Zelcer S; Division of Hematology/Oncology, Department of Pediatrics, London Health Sciences Centre & Western University, London, ON, Canada.
  • Youkhanna S; Department Radiation Oncology, London Regional Cancer Centre, London, ON, Canada.
  • Cacciotti C; Division of Hematology/Oncology, Department of Pediatrics, London Health Sciences Centre & Western University, London, ON, Canada.
Front Oncol ; 14: 1366251, 2024.
Article in En | MEDLINE | ID: mdl-38912055
ABSTRACT

Introduction:

Pediatric low-grade gliomas (pLGG) are the most common brain tumor in children and encompass a wide range of histologies. Treatment may pose challenges, especially in those incompletely resected or those with multiple recurrence or progression. Case description We report the clinical course of a girl diagnosed with pilocytic astrocytoma and profound hydrocephalus at age 12 years treated with subtotal resection, vinblastine chemotherapy, and focal proton radiotherapy. After radiotherapy the tumor increased in enhancement temporarily with subsequent resolution consistent with pseudoprogression. Despite improvement in imaging and radiographic local control, the patient continues to have challenges with headaches, visual and auditory concerns, stroke-like symptoms, and poor quality of life.

Conclusion:

pLGG have excellent long-term survival; thus, treatments should focus on maintaining disease control and limiting long-term toxicities. Various treatment options exist including surgery, chemotherapy, targeted agents, and radiation therapy. Given the morbidity associated with pLGG, individualized treatment approaches are necessary, with a multi-disciplinary approach to care focused on minimizing treatment side effects, and promoting optimal quality of life for patients.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Oncol Year: 2024 Type: Article Affiliation country: Canada

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Oncol Year: 2024 Type: Article Affiliation country: Canada