Safety of tenofovir alafenamide in people with HIV who experienced proximal renal tubulopathy on tenofovir disoproxil.
AIDS
; 38(9): 1442-1445, 2024 07 15.
Article
in En
| MEDLINE
| ID: mdl-38932750
ABSTRACT
Twenty-eight individuals who experienced proximal renal tubulopathy (PRT, Fanconi syndrome) while receiving tenofovir disoproxil initiated tenofovir alafenamide (TAF) and were followed for 5 years. None developed recurrent PRT or experienced significant changes in estimated glomerular filtration rate (by creatinine or cystatin-C), albuminuria, proteinuria, retinol-binding proteinuria, fractional excretion of phosphate, alkaline phosphatase, or bone mineral density at the lumbar spine. These data suggest that TAF is a well tolerated treatment option for individuals vulnerable to developing PRT.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenine
/
HIV Infections
/
Anti-HIV Agents
/
Alanine
/
Fanconi Syndrome
/
Tenofovir
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
AIDS
/
AIDS (Lond.)
/
AIDS (London, England)
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
2024
Type:
Article