Vascular syk-ness: A new role for an old immunological favorite.
J Biol Chem
; 300(7): 107517, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38945448
ABSTRACT
Acute respiratory distress syndrome (ARDS) is a deadly clinical presentation in sepsis, COVID, and other lung disorders where vascular fluid leakage is a severe problem. Recent findings by Shadab et al. in the JBC show that a well-known player in immune function, Syk, also regulates vascular leakage in response to sepsis. An existing FDA-approved inhibitor of Syk, fostamatinib, prevents the vascular leakage and improves survival in a mouse sepsis model, providing promise for ARDS treatment in the clinic.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrimidines
/
Respiratory Distress Syndrome
/
Morpholines
/
Protein Kinase Inhibitors
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Syk Kinase
/
Aminopyridines
Limits:
Animals
/
Humans
Language:
En
Journal:
J Biol Chem
Year:
2024
Type:
Article