Bone Marrow Adipose Tissue as a Critical Regulator of Postmenopausal Osteoporosis - A Concise Review.
Clin Interv Aging
; 19: 1259-1272, 2024.
Article
in En
| MEDLINE
| ID: mdl-39011312
ABSTRACT
Postmenopausal osteoporosis (PMOP) is a major health problem affecting millions of women worldwide. PMOP patients are often accompanied by abnormal accumulation of bone marrow adipose tissue (BMAT). BMAT is a critical regulator of bone homeostasis, and an increasing BMAT volume is negatively associated with bone mass reduction or fracture. BMAT regulates bone metabolism via adipokines, cytokines and the immune system, but the specific mechanisms are largely unknown. This review emphasizes the impact of estrogen deficiency on bone homeostasis and BMAT expansion, and the mechanism by which BMAT regulates PMOP, providing a promising strategy for targeting BMAT in preventing and treating PMOP.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Marrow
/
Osteoporosis, Postmenopausal
/
Adipose Tissue
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Clin Interv Aging
Journal subject:
GERIATRIA
Year:
2024
Type:
Article