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Pd-Catalyzed cascade Heck cyclization/carbonylation of indoles with aryl formates: enantioselective construction of indolo[2,1-a]isoquinolines.
Chi, Dongmei; Qi, Hongbo; Wang, Leming; Chen, Shufeng.
Affiliation
  • Chi D; Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, China. shufengchen@imu.edu.cn.
  • Qi H; Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, China. shufengchen@imu.edu.cn.
  • Wang L; Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, China. shufengchen@imu.edu.cn.
  • Chen S; Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, China. shufengchen@imu.edu.cn.
Chem Commun (Camb) ; 60(65): 8613-8616, 2024 Aug 09.
Article in En | MEDLINE | ID: mdl-39046243
ABSTRACT
An efficient palladium-catalyzed cascade cyclization/carbonylation of indoles with aryl formates to access ester-functionalized indolo[2,1-a]isoquinoline scaffolds has been developed. In addition, an asymmetric variant is also achieved using a chiral phosphine ligand, affording the indolo[2,1-a]isoquinoline products in good yields and enantioselectivities.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Type: Article Affiliation country: China