Elucidation of Degradation Behavior of Barbiturates in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (V).
Chem Pharm Bull (Tokyo)
; 72(8): 747-750, 2024.
Article
in En
| MEDLINE
| ID: mdl-39111846
ABSTRACT
The gastric stability of eight barbiturates (BARs) (barbital, primidone, allobarbital, phenobarbital, cyclobarbital, pentobarbital, secobarbital, and thiobutabarbital (TBB)) was examined in artificial gastric juice using LC/UV detection. Among the eight BARs, only TBB was degraded at higher temperatures. Furthermore, the degradation product of TBB was isolated, structurally analyzed, and finally identified as 5-butan-2-yl-5-ethyl-1,3-diazinane-2,4,6-trione, also known as butabarbital. The study elucidated that butabarbital was formed by substituting the sulfur atom of the carbonyl group at the 2-position of TBB with an oxygen atom under acidic condition.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Barbiturates
/
Gastric Juice
Limits:
Humans
Language:
En
Journal:
Chem Pharm Bull (Tokyo)
Year:
2024
Type:
Article