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Two HUSH complexes connect a direct LINE to innate immunity.
Faulkner, Geoffrey J.
Affiliation
  • Faulkner GJ; Mater Research Institute - University of Queensland, Woolloongabba, QLD 4102, Australia; Queensland Brain Institute, University of Queensland, St. Lucia, QLD 4067, Australia. Electronic address: faulknergj@gmail.com.
Mol Cell ; 84(15): 2801-2803, 2024 Aug 08.
Article in En | MEDLINE | ID: mdl-39121841
ABSTRACT
In this issue of Molecular Cell, Danac et al.1 identify a second HUSH complex, HUSH2, that represses interferon-stimulated genes and, by competing for subunits with the canonical HUSH complex, couples LINE-1 (L1) retrotransposon transcription with immune activation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Long Interspersed Nucleotide Elements / Immunity, Innate Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2024 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Long Interspersed Nucleotide Elements / Immunity, Innate Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2024 Type: Article