Monoclonal macroglobulinemia in NZB-NZW F1 mice.
J Exp Med
; 138(4): 989-1002, 1973 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-4200650
ABSTRACT
Serum monoclonal macroglobulins were detected in over 30% of NZB/NZW F(1) mice greater than 11 mo of age. The monoclonal nature of the IgM was shown by restricted electrophoretic mobility, characteristic appearance on immunoelectrophoresis, restriction to a single light chain type, and ability to induce anti-idiotypic antisera. The monoclonal macroglobulins were separated from antibodies to DNA and RNA that migrated in the 7S region of sucrose gradients. Enlarged lymph nodes were often present in mice with monoclonal IgM, and a transplantable IgM-producing lymphoid tumor was established from the spleen of one animal.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin M
/
Macroglobulins
/
Waldenstrom Macroglobulinemia
/
Mice, Inbred NZB
/
Mice, Inbred Strains
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Exp Med
Year:
1973
Type:
Article