Linoleic acid hydroperoxide: impaired bacterial uptake by alveolar macrophages, a mechanism of  oxidant lung injury.

Khandwala, A; Gee, J B

Linoleic acid hydroperoxide: impaired bacterial uptake by alveolar macrophages, a mechanism of oxidant lung injury.

Khandwala, A; Gee, J B.

Science ; 182(4119): 1364-5, 1973 Dec 28.

Article in En | MEDLINE | ID: mdl-4760314

ABSTRACT

ABSTRACT

Exogenous linoleic acid hydroperoxide causes in vitro impairment of both bacterial uptake and the phagocytic stimulation of (14)CO(2) production from [1-(14)C]glucose in rabbit alveolar macrophages by an undefined effect on the cell membrane. This effect may be one mechanism for the defective pulmonary bacterial clearance characteristic of oxidant lung injury.

Subject(s)

Linoleic Acids/pharmacology; Peroxides/pharmacology; Phagocytosis/drug effects; Animals; Carbon Dioxide/biosynthesis; Carbon Radioisotopes; Depression, Chemical; Glucose/metabolism; Glucosephosphate Dehydrogenase/antagonists & inhibitors; Glyceraldehyde-3-Phosphate Dehydrogenases/antagonists & inhibitors; In Vitro Techniques; Macrophages/drug effects; Macrophages/enzymology; Macrophages/metabolism; Phosphogluconate Dehydrogenase/antagonists & inhibitors; Rabbits; Staphylococcus

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Collection: 01-internacional Database: MEDLINE Main subject: Peroxides / Phagocytosis / Linoleic Acids Limits: Animals Language: En Journal: Science Year: 1973 Type: Article

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