Anti-inflammatory steroids without pituitary-adrenal suppression.
Science
; 215(4535): 989-91, 1982 Feb 19.
Article
in En
| MEDLINE
| ID: mdl-6296999
ABSTRACT
When two new steroids, methyl prednisolonate and methyl 20-dihydroprednisolonate, were applied locally their anti-inflammatory activities were nearly equivalent to those of the parent compound prednisolone in the cotton pellet granuloma bioassay. However, when these two derivatives were administered systemically, their anti-inflammatory activities were weaker than those of the parent compound. Furthermore, unlike the parent compound, these new anti-inflammatory steroids did not suppress pituitary-adrenal function or cause liver glycogen depletion in rats.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pituitary-Adrenal System
/
Prednisolone
/
Anti-Inflammatory Agents
Limits:
Animals
Language:
En
Journal:
Science
Year:
1982
Type:
Article