Effect of malignant transformation, retinoic acid, trifluoperazine, and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) on the sensitivity of rodent cells to Pseudomonas toxin.
Cancer Res
; 44(11): 4919-23, 1984 Nov.
Article
in En
| MEDLINE
| ID: mdl-6435858
ABSTRACT
A number of mouse and rat cells and their virus-transformed counterparts were tested for sensitivity to Pseudomonas aeruginosa exotoxin A (PEA). In each case, the transformed cells were considerably less sensitive than were the nontransformed cells. In the presence of trifluoperazine, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, or retinoic acid, the transformed cells became as sensitive as the nontransformed cells, whereas these drugs had little or no effect on the sensitivity to PEA of the nontransformed cells. Temperature-sensitive virus-transformed normal rabbit kidney cells were sensitized to PEA by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, when these cells were grown as the transformed phenotype, whereas the nontransformed phenotype could not be sensitized. The possibility is discussed that upon malignant transformation a process which is dependent upon calmodulin or protein kinase C strongly decreases the sensitivity of the cells to PEA.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfonamides
/
Bacterial Toxins
/
Tretinoin
/
Trifluoperazine
/
Cell Transformation, Neoplastic
/
ADP Ribose Transferases
/
Virulence Factors
/
Exotoxins
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Cancer Res
Year:
1984
Type:
Article