T and B lymphocyte subsets in fenoprofen nephropathy.
Am J Med
; 75(1): 9-16, 1983 Jul.
Article
in En
| MEDLINE
| ID: mdl-6602549
ABSTRACT
Renal failure due to combined acute interstitial nephritis and minimal-change glomerulopathy is reported in two patients after fenoprofen therapy. In the interstitial infiltrates, T lymphocytes predominated over B lymphocytes in a ratio of four to one. The majority of B lymphocytes present were IgE-bearing cells. Among the T cells, the ratio of cytotoxic/suppressor cells to helper-inducer cells was three to one. Repeated renal biopsy in one patient after steroid-induced clinical remission demonstrated resolution of the inflammatory infiltrate and restoration of normal glomerular foot processes. The theoretic and practical implications of these findings are discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenylpropionates
/
B-Lymphocytes
/
T-Lymphocytes
/
Fenoprofen
/
Acute Kidney Injury
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Am J Med
Year:
1983
Type:
Article