6-Mercaptopurine treatment of pregnant mice: effects on second and third generations.
Science
; 201(4350): 65-7, 1978 Jul 07.
Article
in En
| MEDLINE
| ID: mdl-663638
ABSTRACT
The immunosuppressive drug 6-mercaptopurine is embryotoxic in mice. Of the surviving female offspring of mice treated with low doses of 6-mercaptopurine during pregnancy, despite normal body weight and general appearance, many were either sterile or, if they became pregnant, had smaller litters and more dead fetuses as compared to offspring of mothers that had not received the drug.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy, Animal
/
Fetal Death
/
Germ Cells
/
Infertility, Female
/
Mercaptopurine
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Science
Year:
1978
Type:
Article