Synthesis of potential antifilarial agents. 1-(5-Benzoylbenzimidazol-2-yl)-3-alkyl- and -arylureas.

Ram, S; Skinner, M; Kalvin, D; Wise, D S; Townsend, L B; McCall, J W; Worth, D; Ortwine, D; Werbel, L M

Ram, S; Skinner, M; Kalvin, D; Wise, D S; Townsend, L B; McCall, J W; Worth, D; Ortwine, D; Werbel, L M.

J Med Chem ; 27(7): 914-7, 1984 Jul.

Article in En | MEDLINE | ID: mdl-6737434

ABSTRACT

ABSTRACT

A series of 1-(5-benzoylbenzimidazol-2-yl)-3-substituted ureas have been synthesized by reacting an appropriate isocyanate with 2-amino-5-benzoylbenzimidazole or by reacting methyl (5-benzoylbenzimidazol-2-yl)carbamate with various amines. Several of the compounds have demonstrated antifilarial activity against Brugia pahangi and Litomosoides carinii.

Subject(s)

Anthelmintics/chemical synthesis; Benzimidazoles/chemical synthesis; Filaricides/chemical synthesis; Urea/analogs & derivatives; Animals; Benzimidazoles/pharmacology; Brugia/drug effects; Filarioidea/drug effects; Gerbillinae; Male; Urea/chemical synthesis; Urea/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Urea / Benzimidazoles / Filaricides / Anthelmintics Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1984 Type: Article

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