Penetration of netilmicin into heart valves, subcutaneous and muscular tissue of patients undergoing heart surgery.
Clin Cardiol
; 6(5): 217-9, 1983 May.
Article
in En
| MEDLINE
| ID: mdl-6851281
ABSTRACT
In 57 patients undergoing heart surgery concentrations of netilmicin in plasma, heart valves, muscle, and subcutaneous tissue were determined after a 5 min intravenous bolus injection of 1.5 mg/kg body weight. Within 8 h netilmicin serum concentration declined from 3 micrograms/ml to 1 microgram/ml. In heart valves the concentrations during heart surgery were high enough to inhibit most staphylococci, Klebisiella, Enterobacter and Escherichia coli strains. No different serum and tissue concentrations in patients with and without extracorporal circulation could be found.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gentamicins
/
Netilmicin
/
Heart Diseases
/
Heart Valves
/
Myocardium
Limits:
Humans
Language:
En
Journal:
Clin Cardiol
Year:
1983
Type:
Article