Mature bone marrow erythroid burst-forming units do not require T cells for induction of erythropoietin-dependent differentiation.
J Exp Med
; 152(2): 350-60, 1980 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-6967513
ABSTRACT
Cell-cell interactions between mature T cells and peripheral blood null cells induce erythropoietin-stimulated differentiation of peripheral blood-derived erythroid progenitors. By the use of complement-fixing cytolytic murine hybridoma and antibody uniquely reactive with mature T lymphocytes, this dependence of immature peripheral blood erythroid burst-forming unit (BFU-E) differentiation upon mature T cells or a T cell conditioned medium is confirmed. By using the same antibody, it is demonstrated that the differentiation of mature bone marrow BFU-E does not require either mature T cells or lymphocyte mitogenic factor. These findings do not preclude the presence in the bone marrow of other cells, perhaps even immature T cells, that influence erythropoietin-dependent erythroid differentiation of mature marrow BFU-E.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Marrow Cells
/
Hematopoietic Stem Cells
/
T-Lymphocytes
/
Cell Differentiation
/
Erythropoietin
/
Erythropoiesis
Limits:
Humans
Language:
En
Journal:
J Exp Med
Year:
1980
Type:
Article