Antitumor agents XXXVI: Structural elucidation of sesquiterpene lactones microhelenins-A, B, and C, microlenin acetate, and plenolin from Helenium microcephalum.
J Pharm Sci
; 69(9): 1044-9, 1980 Sep.
Article
in En
| MEDLINE
| ID: mdl-7411405
ABSTRACT
The antitumor sesquiterpene lactones microhelenins-A, B, and C, microlenin acetate, and plenolin were isolated from Helenium microcephalum. The structures and stereochemistry of these lactones were determined by physical methods as well as by chemical transformations and correlations. Microlenin acetate appears to be the first novel dimeric sesquiterpene lactone demonstrated to have significant antileukemic activity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plants, Medicinal
/
Sesquiterpenes
/
Antineoplastic Agents, Phytogenic
Language:
En
Journal:
J Pharm Sci
Year:
1980
Type:
Article