Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.

Meinl, E; Weber, F; Drexler, K; Morelle, C; Ott, M; Saruhan-Direskeneli, G; Goebels, N; Ertl, B; Jechart, G; Giegerich, G

Meinl, E; Weber, F; Drexler, K; Morelle, C; Ott, M; Saruhan-Direskeneli, G; Goebels, N; Ertl, B; Jechart, G; Giegerich, G.

Affiliation

Meinl E; Department of Neuroimmunology, Max-Planck-Institute of Psychiatry, Martinsried, Germany.

J Clin Invest ; 92(6): 2633-43, 1993 Dec.

Article in En | MEDLINE | ID: mdl-7504690

Subject(s)

Multiple Sclerosis/immunology; Myelin Basic Protein/immunology; T-Lymphocytes/immunology; Adult; Amino Acid Sequence; Base Sequence; Brain Chemistry; DNA/biosynthesis; DNA Primers; Epitopes/analysis; Female; HLA Antigens/blood; HLA-D Antigens/blood; Humans; Lymphocyte Activation; Male; Middle Aged; Molecular Sequence Data; Multiple Sclerosis/blood; Myelin Basic Protein/isolation & purification; Myelin Basic Protein/pharmacology; Polymerase Chain Reaction; Receptors, Antigen, T-Cell/biosynthesis; Receptors, Antigen, T-Cell, alpha-beta/biosynthesis; Reference Values; T-Lymphocytes/drug effects; Thymidine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Myelin Basic Protein / Multiple Sclerosis Type of study: Clinical_trials Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Clin Invest Year: 1993 Type: Article Affiliation country: Germany

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